James Gaskell will lead England Saxons for the first time against the O2 Ireland Wolfhounds at Exeter on Saturday (5pm).
Gaskell, 21, captained Sale Sharks last season and leads a side with an average age of just 24 years and four months at Sandy Park. It includes senior internationals Delon Armitage, Matt Banahan, Ugo Monye, Matt Mullan and Paul Doran-Jones in the starting line-up.
Centre Matt Hopper, half backs Freddie Burns and Ben Spencer, and No. 8 Thomas Waldrom feature for the Saxons for the first time with more newcomers on the bench in the shape of hooker Chris Brooker and wing Jonny May.
15 Delon Armitage (London Irish)
14 Ugo Monye (Harlequins)
13 Matt Hopper (Harlequins)
12 Billy Twelvetrees (Leicester Tigers)
11 Matt Banahan (Bath Rugby)
10 Freddie Burns (Gloucester Rugby)
9 Ben Spencer (Saracens)
1 Matt Mullan (Worcester Warriors)
2 Joe Gray (Harlequins)
3 Paul Doran-Jones (Northampton Saints)
4 Matt Garvey (London Irish)
5 George Robson (Harlequins)
6 James Gaskell (Sale Sharks, captain)
7 Andy Saull (Saracens)
8 Thomas Waldrom (Leicester Tigers)
Replacements: 16 Chris Brooker (Harlequins), 17 Rupert Harden (Gloucester), 18 Kearnan Myall (Sale Sharks), 19 Tom Johnson (Exeter Chiefs), 20 Paul Hodgson (London Irish), 21 Ryan Lamb (Northampton Saints), 22 Jonny May (Gloucester Rugby).